Pre-mRNA-splicing factor RBM22

Protein information

Protein ID: Q9NW64
Protein Name : Pre-mRNA-splicing factor RBM22
Gene : RBM22
Organism : Homo sapiens

Status : reviewed
Function : Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28502770 PubMed:28076346 PubMed:29361316 PubMed:29360106 PubMed:29301961 PubMed:30705154). Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.

Protein Sequence

MATSLGSNTYNRQNWEDADFPILCQTCLGENPYIRMTKEKYGKECKICARPFTVFRWCPGVRMRFKKTEVCQTCSKLKNVCQTCLLDLEYGLPIQVRDAGLSFKDDMPKSDVNKEYYTQNMEREISNSDGTRPVGMLGKATSTSDMLLKLARTTPYYKRNRPHICSFWVKGECKRGEECPYRHEKPTDPDDPLADQNIKDRYYGINDPVADKLLKRASTMPRLDPPEDKTITTLYVGGLGDTITETDLRNHFYQFGEIRTITVVQRQQCAFIQFATRQAAEVAAEKSFNKLIVNGRRLNVKWGRSQAARGKEKEKDGTTDSGIKLEPVPGLPGALPPPPAAEEEASANYFNLPPSGPPAVVNIALPPPPGIAPPPPPGFGPHMFHPMGPPPPFMRAPGPIHYPSQDPQRMGAHAGKHSSP

RRM domains in this Protein - 1

RRM Entryname	RRM Sequence range	Pfam ID
Q9NW64_RRM1	234 - 299	PF00076

Experiments retrieved for this Protein - 14

Experiment ID	Experiment Type	PubMed ID
Exp_2YTC	NMR
Exp_5MQF	EM	28076346
Exp_5XJC	EM	28502770
Exp_5YZG	EM	29301961
Exp_5Z56	EM	29360106
Exp_5Z57	EM	29360106
Exp_6FF4	EM	29361316
Exp_6FF7	EM	29361316
Exp_6ICZ	EM	30728453
Exp_6ID0	EM	30728453
Exp_6ID1	EM	30728453
Exp_6QDV	EM	30705154
Exp_7A5P	EM	33007253
Exp_7ABI	EM	33243851

Ligands tested for Binding - 6

Ligand ID	Ligand Type	Ligand Sequence
Lig109	RNA	GAAUACACGGAAUUCGAGCUCGCCCACUCUUGGAUCGGAAACCCGUCGGCCUCCGAACGGUAAGAGCCUAGCAUGUAGAACUGGUUACCUGCAGCCCAAGCUUGCGUACACCAUCAGGGUACGUACUAGUACGUACACCAUCAGGGUACGGCUGCACGUCUAGGGCGCAGUAGUCCAGGGUUUCCUUGAUGAUGUCAUACUUAUCCUGUCCCUUUUUUUUCCACAGCUCGCGGUUGAGGACAAACUCUUCGCGGUCUUUCCAGUGGGGAUCC
Lig112	RNA	GGGAAUACACGGAAUUCGAGCUCGCCCACUCUUGGAUCGGAAACCCGUCGGCCUCCGAACGXGUAAGAGCCUAGCAUGUAGAACUGGUUACCUGCAGCCCAAGCUUGCGUACACCAUCAGGGUACGUACUAGUACGUACACCAUCAGGGUACGGCUGCACGUCUAGGGCGCAGUAGUCCAGGGUUUCCUUGAUGAUGUCAUACUUAUCCUGUCCCUUUUUUUUCCACGGCUCGCGGUUGAGGACAAACUCUUCGCGGUCUUUCCAGUGGGGAUCC
Lig12	RNA	GAAUACACGGAAUUCGAGCUCGCCCACUCUUGGAUCGGAAACCCGUCGGCCUCCGAACGNGUAAGAGCCUAGCAUGUAGAACUGGUUACCUGCAGCCCAAGCUUGCGUACACCAUCAGGGUACGUACUAGUACGUACACCAUCAGGGUACGGCUGCACGUCUAGGGCGCAGUAGUCCAGGGUUUCCUUGAUGAUGUCAUACUUAUCCUGUCCCUUUUUUUUCCACAGCUCGCGGUUGAGGACAAACUCUUCGCGGUCUUUCCAGUGGGGAUCC
Lig182	RNA	GGGAAUACACGGAAUUCGAGCUCGCCCACUCUUGGAUCGGAAACCCGUCGGCCUCCGAACGNGUAAGAGCCUAGCAUGUAGAACUGGUUACCUGCAGCCCAAGCUUGCGUACACCAUCAGGGUACGUACUAGUACGUACACCAUCAGGGUACGGCUGCACGUCUAGGGCGCAGUAGUCCAGGGUUUCCUUGAUGAUGUCAUACUUAUCCUGUCCCUUUUUUUUCCACGGCUCGCGGUUGAGGACAAACUCUUCGCGGUCUUUCCAGUGGGGAUCC
Lig48	RNA	GGGAGACGGAAUUCGAGCUCGCCCACUCUUGGAUCGGAAACCCGUCGGCCUCCGAACGGUAAGAGCCUAGCAUGUAGAACUGGUUACCUGCAGCCCAAGCUUGCUGCACGUCUAGGGCGCAGUAGUCCAGGGUUUCCUUGAUGAUGUCAUACUUAUCCUGUCCCUUUUUUUUCCACAGCUCGCGGUUGAGGACAAACUCUUCGCGGUCUUUCCAGUGGGGAUCCGAUAUCCGUACACCAUCAGGGUACGAGCUAGCCCAUGGCGUACACCAUCAGGGUACGACUAGUAGAUCUCGUACACCAUCAGGGUACGGAAUUCUCUAGA
Lig91	RNA	GGGAAUACACGGAAUUCGAGCUCGCCCACUCUUGGAUCGGAAACCCGUCGGCCUCCGAACGGUAAGAGCCUAGCAUGUAGAACUGGUUACCUGCAGCCCAAGCUUGCGUACACCAUCAGGGUACGUACUAGUACGUACACCAUCAGGGUACGGCUGCACGUCUAGGGCGCAGUAGUCCAGGGUUUCCUUGAUGAUGUCAUACUUAUCCUGUCCCUUUUUUUUCCACGGCUCGCGGUUGAGGACAAACUCUUCGCGGUCUUUCCAGUGGGGAUCC