U2 small nuclear ribonucleoprotein B''

Protein information

  • Protein ID: P08579
  • Protein Name : U2 small nuclear ribonucleoprotein B''
  • Gene : SNRPB2
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638 PubMed:28502770 PubMed:28781166 PubMed:28076346). Associated with sn-RNP U2 where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:9716128).

Protein Sequence

  • MDIRPNHTIYINNMNDKIKKEELKRSLYALFSQFGHVVDIVALKTMKMRGQAFVIFKELGSSTNALRQLQGFPFYGKPMRIQYAKTDSDIISKMRGTFADKEKKKEKKKAKTVEQTATTTNKKPGQGTPNSANTQGNSTPNPQVPDYPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAARDALQGFKITPSHAMKITYAKK

RRM domains in this Protein - 2 

RRM Entryname RRM Sequence range Pfam ID
P08579_RRM1 9 - 80 PF00076
P08579_RRM2 153 - 219 PF00076

RRM domain Linkers in this Protein - 1 

Linker Name Linker Sequence range
P08579_linker1 81 - 152

Experiments retrieved for this Protein - 21 

Experiment ID Experiment Type PubMed ID
Exp_1A9N X-ray Diffraction 9716128
Exp_5MQF EM 28076346
Exp_5O9Z EM 28781166
Exp_5XJC EM 28502770
Exp_5YZG EM 29301961
Exp_5Z56 EM 29360106
Exp_5Z57 EM 29360106
Exp_5Z58 EM 29360106
Exp_6AH0 EM 30315277
Exp_6AHD EM 30315277
Exp_6FF7 EM 29361316
Exp_6ICZ EM 30728453
Exp_6ID0 EM 30728453
Exp_6ID1 EM 30728453
Exp_6QDV EM 30705154
Exp_6QX9 EM 30975767
Exp_6Y53 EM 32494006
Exp_6Y5Q EM 32494006
Exp_7A5P EM 33007253
Exp_7ABG EM 33243851
Exp_7ABI EM 33243851

Ligands tested for Binding - 5 

Ligand ID Ligand Type Ligand Sequence
Lig129 RNA CCUGGUAUUGCAGUACCUCCAGGU
Lig18 RNA AUCGCUUCUCGGCCUUUUGGCUAAGAUCAAGUGUAGUAUCUGUUCUUAUCAGUUUAAUAUCUGAUACGUCCUCUAUCCGAGGACAAUAUAUUAAAAGAUUUUUGGAACUCAGGGAGAUGGAAUAGGAGCUUGCUCCGUCCACUCCACGCAUCGACCUGGUAUUGCAGUACCUCCAGGAACGGUGCACCC
Lig27 RNA AACGGCGGAGGCCACGCCCUCUGUGAAAGGGCGGGGCAUGCAAAUUCGAAAUGAAAGCCCGGGAACGCCGGAAGAAGCACGGGUGUAAGAUUUCCCUUUUCAAAGGCGGAGAAUAAGAAAUCAGCCCGAGAGUGUAAGGGCGUCAAUAGCGCUGUGGACGAGACAGAGGGAAUGGGGCAAGGAGCGAGGCUGGGGCUCUCACCGCGACUUGAAUGUGGAUGAGAGUGGGACGGUGACGGCGGGCGCGAAGGCGAGCGCAUCGCUUCUCGGCCUUUUGGCUAAGAUCAAGUGUAGUAUCUGUUCUUAUCAGUUUAAUAUCUGAUACGUCCUCUAUCCGAGGACAAUAUAUUAAAUGGAUUUUUGGAGCAGGGAGAUGGAAUAGGAGCUUGCUCCGUCCACUCCACGCAUCGACCUGGUAUUGCAGUACCUCCAGGAACGGUGCACCCCCUCCGGGGUACAACGUGUUUCCUAAAAGUAGAGGGAGGUGAGAGACGGUAGCACCUGCGGGGCGGCUUGCACGCCGAGUGCCUGUGACGCGCCGGCUUGACUUAACUGCUUCCCUGAAGUACCGUGAGGUUCCUGAUGUGCGGGCGGUAGACGGUAGGCUUAUGCGGCACGCUUUCGUUUCCACCGUGGCUACUGCGCUUUGGGAAGGCCACGACCUCCUCCUUUGGGGAGGUCCUUAGGAUCUCAGCUUGGCAGUCGAGUGGGUGGCGACCUUUUAAAGGAAUGGGACCCACCCGGAGUUCUUCUUUCUCCUGUCUCUCUCUCUCUCUCUCUCUCUCUCUCUCUCUCUCUCUCUUUCUCUCUCUCUCUCUGUCUCUCCGUCUCUCUGUGUCUGUCUCUGUCUCUCUGUCUCUCUCUCUCUCUCUCUCUCUCUCUCCUCUCUCUGUCUCUCUCUCUCUUUCCCCCCCCCUCCCCGCCUCUCCCUCGCUCUCUCUUUUGGUUUCCCCCACCCCCUCCCAAGUUCUGGGG
Lig53 RNA AUCGCUUCUCGGCCUUUUGGCUAAGAUCAAGUGUAGUAUCUGUUCUUAUCAGUUUAAUAUCUGAUACGUCCUCUAUCCGAGGACAAUAUAUUAAAUAGAUUUUUGGAGCAGGGAGAUGGAAUAGGAGCUUGCUCCGUCCACUCCACGCAUCGACCUGGUAUUGCAGUACCUCCAGGAACGGUGCACCC
Lig80 RNA AUCGCUUCUCGGCCUUUUGGCUAAGAUCAAGUGUAGUAUCUGUUCUUAUCAGUUUAAUAUCUGAUACGUCCUCUAUCCGAGGACAAUAUAUUAAAUGGAUUUUUGGAGCAGGGAGAUGGAAUAGGAGCUUGCUCCGUCCACUCCACGCAUCGACCUGGUAUUGCAGUACCUCCAGGAACGGUGCACCC